Lupine Publishers Current Trends in Gastroenterology and Hepatology

  Abstract Extra pulmonary symptoms may contribute to poor outcome in COVID-19. We compared the frequency of gastrointestinal and sensory manifestations (GSM) between mild and severely ill patients with COVID-19, alone or combined with classic respiratory manifestations (CRM). Hospitalized patients with COVID-19 (n = 357) were classified according to their disease severity by using a neutrophile/lymphocyte ratio value ≥18 for severe illness. Presence of CRM and baseline clinical data were recorded. Presence of >3 liquid evacuations per day (diarrhea), decreased usual bowel movements (constipation), nausea/vomiting, lack of appetite (anorexia), abdominal pain, loss of taste (dysgeusia) and/or loss of smell (anosmia) were personally recorded by the investigators at the study admission. Severely ill patients (47.3%) presented worse clinical markers than mildly ill patients, including higher risk of malnutrition and higher need for non-invasive respiratory support ...

  Opinion Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of progressive liver abnormalities from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH) to advanced fibrosis, cirrhosis, and/or hepatocellular carcinoma [1]. Parallel to the rising burden of obesity and metabolic syndrome, NAFLD has emerged as the leading cause of chronic liver disease at an estimated global prevalence of 24% [2]. Besides its known clinical burden for liver-related morbidity and mortality, NAFLD is potentially linked with other extra-hepatic chronic diseases and may be considered a multisystem condition. Particularly, NAFLD increases the risk of type 2 diabetes, cardiovascular diseases, chronic kidney disease, and all-cause mortality [1]. Potential pathophysiologic mechanisms underlying the detrimental effects of NAFLD include hyperglycemia, systemic inflammation, and increased oxidative stress [3]. Sodiumglucose cotransporter 2 (SGLT2) inhibitors are a new class of ...

Abstract Post-COVID-19 gastrointestinal (GI) disease management remains a clinical challenge as the medical literature continues to evolve and expand. Reports of excess GI disease burden across the population, as well as prescribed use of pharmaceuticals for symptom relief, have proven “long-haul” GI disease is prevalent across the population. This article will help to summarize the current medical literature as it pertains to post-COVID-19 GI clinical presentations, dysbiosis, functional disorders and evidence of lasting liver and biliary injury implications. Increased awareness of the GI implications for this paradigm hopefully will lead to a better understanding of the pathophysiology, as well as natural history and potential therapeutic approaches. Read more about this article: https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/post-covid-19-gi-manifestations-are-we-in-for-the-long-haul.ID.000158.php  Read more about Lupine Publishers Go...

  Abstract Introduction: A case presented to the public demonstrates the possibility of treatment with Sirolimus in a patient with progressive multifocal liver Focal Nodular Hyperplasia (FNH) with progressive growth and a tendency to formation of liver function insufficiency after splenorenal shunt for portal hypertension. Material and Methods: Patient E. 08.03.2001 year of birth c Diagnosed with multifocal bilobar nodular liver hyperplasia after splenorenal bypass surgery for portal hypertension, established in 2018/ Sirolimus treatment was prescribed from 06.22.18 to the present. Conclusion: As a result of the treatment with Sirolimus, a normalization of the level of liver enzymes, bilirubin in the blood is noted. According to radiation methods, a reduction in liver size and FNH size is up to 30%. Read more about this article: https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/case-of-application-of-syrolimus-in-a-patient-with-progres...

  Abstract The goal is to assess the impact of biogenetic on the condition of patients with psoriasis Materials and Methods: The study group included 415 patients aged 19 to 65 years (34% of men and 66% of women), in whom irrigoscopy revealed the injection of contrast into the ileum, i.e., the insolvency of the baugine flap (NBZ) was diagnosed, 74 of them suffered from psoriasis. For the detection of chronic intoxication were evaluated the data of clinical manifestations, indican urine, level of middle molecules, blood serum, lipid metabolism, microbial resistance, the hydrogen breath test. Results: NBZ is a chronic endointoxication, which regresses in collaboration with the clinical manifestations of psoriasis after biogenetic. Conclusion: Hypothesized that NBZ is one of the causes of psoriasis, and biogenetica – link in etiopathogenetic method of treatment. Read more about this article: https://lupinepublishers.com/gastroenterology-hepatology-journal/fullt...

Lupine Publishers | Current Trends in Gastroenterology and Hepatology Abstract Over the past several decades, great progress has been made on understanding mechanisms of gastric acid secretion for developing new anti-acid drugs. Until now most commonly used anti-acid drugs are histamine-2 receptor antagonists and proton pump inhibitors (PPIs) for patients to control acid related disease. However, several clinical limitations of these drugs had been reported. Recently, a new generation of potassium-competitive acid blockers (P-CABs) were launched for clinical use. It has been shown that these new drugs are more convenient and powerful to treat gastric acid-related diseases. In this article, we briefly reviewed the clinical use of this new anti-acid drug P-CAB. Keywords: Potassium-competitive Acid Blocker; Potassium channel; H+/K+-ATPase Introduction H+/K+-ATPase (or proton pump), which is expressed in gastric parietal cells, is one of the...

Lupine Publishers |Current Trends in Gastroenterology and Hepatology Abstract Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and is one of the major causes of cancerrelated deaths. HCC is reported to be the second most fatal malignancy. The major risk factors for HCC are well known; the known risk factors include hepatitis C virus (HCV) and hepatitis B virus (HBV). Major advances have been reported in the treatment of HCC. Success of early diagnosis increases when these risk factors are identified, and the cases are followed up. It is reported that in the treatment of early-diagnosed HCC cases, ethanol injection or radiofrequency ablation methods as well as surgical resection should be preferred, particularly in cases without liver cirrhosis and in cases where the tumor is restricted. Similarly, liver transplantation may be an option for patients that meet specific criteria. Keywords: Hepatocellular Carcinoma; Liver Carcinoma; ...

Lupine Publishers | Journal of Gastroenterology and Hepatology Abstract Laparoscopic cholecystectomy (LC) is nowadays the procedure of choice for cholecystitis. The intraoperative finding can make this procedure quite tricky such as dense adhesions at calot’s triangle, fibrotic and contracted gallbladder, acutely inflamed or gangrenous gallbladder, cholcystoenteric fistula, etc. There are also risk factors which make laparoscopic surgery difficult like old age, male sex, obesity, previous abdominal surgery, thickened gallbladder wall, distended gallbladder, pericholecystic fluid collection, impacted stone, etc. Methods: This is a one cohort retrospective review of patients admitted to the hospital with acute cholecystitis who during LC were converted to intraoperative cholecystostomy tube placement (CCT) or to open cholecystectomy (OC). Preoperative risk factors to predict difficult cholecystectomy were evaluated. Results: Medical records were reviewed retro...

Over View of Gastro Intestinal Diseases in UAE by Makki H Fayadh in C urrent Trends in Gastroenterology and Hepatology - Lupine Publishers Short Communication One fifth of the population in UAE suffers from gastrointestinal diseases including obesity, reflux disease and fatty liver because of obesity, poor diets and close marriage, Acid reflux, ulcerative colitis and irritable bowel syndrome are increasing in recent years [1-3]. There are also a high number of sufferers of fatty liver, caused to a large extent by the excessive consumption of sugary drinks. Obesity is an issue that can affect the UAE’s development as a nation and needs to be managed immediately and effectively, vague discomfort is usually the only symptom of a fatty liver. Low fiber diets, lack of exercise and consuming large amounts of food and dairy products are responsible for the majority. Genetics combined with obesity are responsible for people suffering from many disorders. A case of fatty liver,...

Risk Predictive Factors to Convert Laparoscopic Cholecystectomy into Other Procedures by Eldo E Frezza in Lupine Publishers Abstract Laparoscopic cholecystectomy (LC) is nowadays the procedure of choice for cholecystitis. The intraoperative finding can make this procedure quite tricky such as dense adhesions at calot’s triangle, fibrotic and contracted gallbladder, acutely inflamed or gangrenous gallbladder, cholcystoenteric fistula, etc. There are also risk factors which make laparoscopic surgery difficult like old age, male sex, obesity, previous abdominal surgery, thickened gallbladder wall, distended gallbladder, pericholecystic fluid collection, impacted stone, etc. Methods: This is a one cohort retrospective review of patients admitted to the hospital with acute cholecystitis who during LC were converted to intraoperative cholecystostomy tube placement (CCT) or to open cholecystectomy (OC). Preoperative risk factors to predict difficult cholecystectomy w...