Lupine Publishers Current Trends in Gastroenterology and Hepatology

  Abstract Extra pulmonary symptoms may contribute to poor outcome in COVID-19. We compared the frequency of gastrointestinal and sensory manifestations (GSM) between mild and severely ill patients with COVID-19, alone or combined with classic respiratory manifestations (CRM). Hospitalized patients with COVID-19 (n = 357) were classified according to their disease severity by using a neutrophile/lymphocyte ratio value ≥18 for severe illness. Presence of CRM and baseline clinical data were recorded. Presence of >3 liquid evacuations per day (diarrhea), decreased usual bowel movements (constipation), nausea/vomiting, lack of appetite (anorexia), abdominal pain, loss of taste (dysgeusia) and/or loss of smell (anosmia) were personally recorded by the investigators at the study admission. Severely ill patients (47.3%) presented worse clinical markers than mildly ill patients, including higher risk of malnutrition and higher need for non-invasive respiratory support ...

  Abstract The identification of the calcium ration by self-questionnaires validated in the region of Blida and the Wilayas of approximately is one of the rare studies in Algeria. She was interested in a part of the Algerian population with characteristics that do not seem very different from the general population; however, this dietary survey must be supplemented by a study on a representative sample of the general population. The study showed insufficient calcium intake mainly secondary to low consumption of milk and dairy products. This low calcium intake was objectified by the two questioning methods (Fardellone and CERIN), however, it will be desirable to establish Algerian self-questionnaires validated and verified by our learned society. The results obtained are worrying, which obliges us to immediately introduce a prevention and control strategy against the multiple pathologies linked to this low calcium intake, the main one being osteoporosis with its seri...

  Abstract The identification of the calcium ration by self-questionnaires validated in the region of Blida and the Wilayas of approximately is one of the rare studies in Algeria. She was interested in a part of the Algerian population with characteristics that do not seem very different from the general population; however, this dietary survey must be supplemented by a study on a representative sample of the general population. The study showed insufficient calcium intake mainly secondary to low consumption of milk and dairy products. This low calcium intake was objectified by the two questioning methods (Fardellone and CERIN), however, it will be desirable to establish Algerian self-questionnaires validated and verified by our learned society. The results obtained are worrying, which obliges us to immediately introduce a prevention and control strategy against the multiple pathologies linked to this low calcium intake, the main one being osteoporosis with its se...

  Introduction Aristolochic acid (AAs) is a group of nitrophenanthrene compounds comprised of AAI, AAII, AAIII and AAIV, which are widely found in Aristolochia plants and used in herbal therapy and traditional Chinese medicine [1]. Consistent use of aristolochic acids- containing drugs could lead to aristolochic acid nephropathy and subsequent urinary tract tumors [2-4]. Active metabolites of AAs form adducts with DNA, inducing characteristic A-T transversion (A:T to T:A mutation) known as AA mutational signature [5]. In 2017, a study has analyzed AA mutational signature of several datasets and concluded that AAs and their derivatives were widely implicated in liver cancers in Taiwan and throughout Asia [6]. Ever since the paper published, there has been an intensive debate on whether the prevalence of AA signature mutation is high in HCC patients and if this mutation spectra is really correlate with traditional Chinese medicine consumption in Asia. Since no case report...

  Opinion Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of progressive liver abnormalities from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH) to advanced fibrosis, cirrhosis, and/or hepatocellular carcinoma [1]. Parallel to the rising burden of obesity and metabolic syndrome, NAFLD has emerged as the leading cause of chronic liver disease at an estimated global prevalence of 24% [2]. Besides its known clinical burden for liver-related morbidity and mortality, NAFLD is potentially linked with other extra-hepatic chronic diseases and may be considered a multisystem condition. Particularly, NAFLD increases the risk of type 2 diabetes, cardiovascular diseases, chronic kidney disease, and all-cause mortality [1]. Potential pathophysiologic mechanisms underlying the detrimental effects of NAFLD include hyperglycemia, systemic inflammation, and increased oxidative stress [3]. Sodiumglucose cotransporter 2 (SGLT2) inhibitors are a new class of ...

  Abstract Aim : To determine the aetiologies of acute upper gastrointestinal bleeding (UGIB) in a setting highly endemic for hepatitis B and to describe actual clinical practices in a resource-limited setting. Patients and methods: This study was conducted in two parts. The first part was retrospective from January 1st 2010, to December 31st 2019 on the epidemiological profile of UGIB and the second was a prospective study from December 1st 2017 to May 31st 2018 to evaluate, in a blinded experiment, the actual clinical practices in front of an acute UGIB at the emergency units in Yaounde (Cameroon), and included: recognizing UGIB, assessing for severity, taking emergency measures and prescribing emergency Eosogastroduodenal endoscopy (EGDE). Results : During the retrospective period, 506 patients (prevalence of acute UGIB in the services 5.6%) were included of which 71.3% were men (sex ratio 2.5). The mean age was 49.9 +/- 8 years. Haematemesis was inaugural in 35...

  Abstract Background : Non-alcoholic fatty liver disease is not simply the hepatic manifestation of obesity and diabetes but also linked to hepatocellular carcinoma. Yet, its effective treatment has not been established. In this study, we evaluated the effect of a short-term administration of luseogliflozin to patients with type 2 diabetes having non-alcohol fatty liver disease. Luseogliflozin is a unique sodium-glucose cotransporter 2 inhibitor which is metabolized in and excreted by the liver in addition to the kidney. Therefore, the drug might possess an additional effect on other agents of the same class which are exclusively metabolized in the kidney. Methods : Using alanine aminotransferase >20 IU/L as a diagnostic basis for non-alcoholic fatty liver disease, 19 patients, not taking alcohol, with type 2 diabetes (male/female 15/4, the median age 57 years) was treated with 2.5 mg luseogliflozin for 12 weeks. Results : Pre- and post-treatment median values...

  Abstract Background : Metabolic bone disorders are frequent in patients with cirrhosis. These two conditions are usually misdiagnosed in Sub-Saharan Africa before the onset of complications. A full evaluation of metabolic bone disorders in patients with liver cirrhosis is difficult in our milieu and osteodensitometry is rarely available. In this preliminary study, we sought to determine the necessity of a cost-effective method, the Nordin’s Index, in the evaluation of osteoporosis in patients with liver cirrhosis. Methods : This was a prospective cross-sectional study from January to May 2017 in Yaoundé. We compared the data of 19 patients (15 men, 4 women) with post viral liver cirrhosis and 17 controls (13 men, 4 women) paired with age, gender and body mass index (BMI). Data collected included vitamin D levels, serum and urine concentrations of calcium and phosphorus, Nordin’s Index and results of the bone mineral density using an x-ray absorptiometry sc...

  Abstract Nonalcoholic fatty liver disease (NAFLD) is described as exposition of multiplex liver metabolic disturbance interconnected with obesity. NAFLD is depicted by steatosis, excessive accumulation of fats in liver, due to triglycerides export and oxidation of fatty acid from plasma and de novo synthesis. Hepatic steatosis can therefore be explained as biochemical outcome of inconsistency between interfused mechanisms of lipid biotransformation. This condition is allied to a range of various modifications in lipoproteins, fatty acids, and glucose metabolisms in organism. So, above metabolic disfunctions are suspected to be the origin of possibility for adverse cardiometabolic risk agents related to NAFLD, like dyslipidemia, Type 2 diabetes mellitus (T2DM), and insulin resistance. Reactive oxygen species (ROS) generation participates as known inducer of inflammation and oxidative stress, that exacerbate this disease. These disorders are hallmarks that worsen ...

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Description of Plasma Concentrations of Free Amino Acidswith Some Clinical Symptoms of Patients Under 5 withShort Bowel Syndrome by Luu Thi My Thuc in Current Trends in Gastroenterology and Hepatology in Lupine Publishers. Amino acid (AA) is the main component of proteins. Changes in levels of plasma AA concentration have been mentioned in some cases such as plasma AA concentrations in chronic kidney disease (CKD) patients are low when inflammation status increases [1] or patients with short bowel syndrome (SBS) undergoing total parenteral nutrition (TPN) have decreasing concentrations of essential amino acids (EAA), increasing rate of malnutrition and complications while for those undergoing part of parenteral nutrition (PN), there was just a decrease in concentrations of two branched chain amino acids, leucin, valine, cysteine, and tyrosine [2]. Autistic children had significant lower plasma levels of leucine, isoleucine, phenylalanine, methionine, cysteine, serine, ty...

Reproductive Health and Fertility in Transition Clinic for Liver Transplant Patients by Uyen in Current Trends in Gastroenterology and Hepatology in Lupine Publishers. The transition of an adolescent into adulthood is fraught with complexity under the best of circumstances. Misinformation or a lack of medical knowledge during this critical time can place young adults in a position to develop risky behaviors. However, simple well-timed educational interventions can foster healthy, informed decisions which can last a lifetime. Adolescents who have undergone pediatric liver transplantation are a subgroup of teenagers at a particularly elevated risk, in part due to their immunosuppression and comorbid conditions, during this time of developing personal autonomy. As these patients begin to develop and establish their personal and reproductive identities, they may also have limited understanding of the long-term consequences of their decisions about reproductive health, contr...

The Burgeoning Role of the Gastrointestinal Microbiota by Martin Floch in Current Trends in Gastroenterologyand Hepatology in Lupine Publishers. With the release of the landmark publication containing the information that there were more microorganisms in the gastrointestinal tract than any other cells [1] the scienti􀏐ic community began to look at the functional role of these organisms. We edited a book on “The Microbiota in Gastrointestinal Pathophysiology; with emphasis on probiotics, prebiotics, and dysbiosis” [2] The book was published in 2018 but since that time a great deal of new information and manuscripts have appeared. Particularly in the area of probiotics and supplements containing probiotics or prebiotics so that organizations are now sponsoring national and international meetings on the subject. https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/the-burgeoning-role-of-the-gastrointestinal-microbiota.ID.000125.php   http...

The Role of Transabdominal Sonography in theDiagnostics of Choledocholithiasis: Compared toEndoscopic Retrograde Cholangiopancreatography by Kanan Yusif-zada KR in Current Trends in Gastroenterologyand Hepatology in Lupine Publishers Common bile duct stone (CBDS) or choledocholithiasis (ChL) is one of the major pathologies that lead to serious complications, and accurate and early diagnosis is very important. ChL diagnostics is based on clinical, laboratory and instrumental examinations. We used transabdominal songraphy (TAUS) for detecting CBDS and comparing it with endoscopic retrograde cholangiopancretography (ERCP). https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/the-role-of-transabdominal-sonography-in-the-diagnostics.ID.000124.php   https://lupinepublishers.com/gastroenterology-hepatology-journal/pdf/CTGH.MS.ID.000124.pdf   For more Lupine Publishers Open Access Journals Please visit our website:http://www.lupinepu...

Lupine Publishers LLC isa world’s leading Online Publishing repository, a genuine publisher with quality medical journals. Lupine Publishers LLC peer reviewed publisher is a multidisciplinary, scholarly Open Access publisher focused on Genetic, Biomedical and Remedial missions in relation with Technical Knowledge as well. Lupine Publishers LLC Online Open Access Publisher,craves to select ground- breaking research based on modernism, aptness, scientific connotation, prospective spectator’s interests, setc. Lupine Publishers LLC Online Open Access Publisher endeavor to provide by far and liberally accessible belvedere to researchers and practitioners in support of their novel and valuable ideas. Lupine Publishers LLCOnline Open Access Publisher already have 2000+ Editorial Board members along with 5000+ Published articles with them. Lupine Publishers LLC Online Open Access journals maintains a scrupulous, methodical, fair peer review System. Besides, quality control is riveted in ...

Portal Hypertensive Gastric Polyps by Umadevi Malladi in Current Trends in Gastroenterologyand Hepatology in Lupine Publishers Portal hypertension is associated with an increased number of gastric polyps, hence the term portal hypertension-associated gastric polyps. Histopathological examination reveals mucosal hyperplasia and vascular proliferation. Formation may be due to mucosal injury that is vascular in nature. Their malignant potential has not been fully elucidated; however, lesions can grow to a large size. Patients with portal hypertension are at increased risk of post polypectomy bleeding and other complications of polypectomy. Surveillance is likely to be safer than multiple polypectomies, therefore in patients with portal hypertension it is essential that gastric polyps are photographed and biopsied during routine surveillance gastroscopies.  https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/portal-hypertensive-gastric-polyps.ID.000...

Primary Liver Cancer in Adults by Mirta D Ambra in Current Trends in Gastroenterologyand Hepatology in Lupine publishers Liver cancer includes two main types: hepatocellular carcinoma (HCC) and intrahepatic bile duct cancer. Incidence and mortality. Calculation of the number of new cases and deaths due to liver and intrahepatic bile duct cancer in the United States in 2018: I. New cases: 42 220. II. Deaths: 30 200. HCC is relatively rare in the United States, although its incidence is increasing, especially in regard to the spread of infection with the hepatitis C virus (HCV). HCC is the most common solid tumor in the world and the third leading cause of cancer-related deaths. https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/primary-liver-cancer-in-adults.ID.000122.php   https://lupinepublishers.com/gastroenterology-hepatology-journal/pdf/CTGH.MS.ID.000122.pdf   https://lupinepublishers.com/gastroenterology-hepatology-journal...

 Lupine publishers LLC | Lupine Publishers Review Lupine Publishers LLC isa world’s leading Online Publishing repository, a genuine publisher with quality medical journals. Lupine Publishers LLC peer reviewed publisher is a multidisciplinary, scholarly Open Access publisher focused on Genetic, Biomedical and Remedial missions in relation with Technical Knowledge as well. Lupine Publishers LLC Online Open Access Publisher,craves to select ground- breaking research based on modernism, aptness, scientific connotation, prospective spectator’s interests, setc. Lupine Publishers LLC Online Open Access Publisher endeavor to provide by far and liberally accessible belvedere to researchers and practitioners in support of their novel and valuable ideas. Lupine publishers LLCOnline Open Access Publisher already have 2000+ Editorial Board members along with 5000+ Published articles with them. Lupine Publishers LLC Online Open Access journals maintains a scrupulous, methodical, fair peer r...

Eradication Failure of Helicobacter Pylori Among Children’s Population by Poul Minochkine in Current Trends in Gastroenterology and Hepatology in Lupine Publishers Helicobacter pylori (H. pylori) is a Gram-negative bacterium responsible for the development of gastritis that may further progress to more severe conditions, peptic ulcer disease and gastric cancer [1,2]. H. pylori have infected from 80% to 90% of the population in Russia [3]. Despite the ongoing discussion on which H. pylori infected patients should be treated up till full eradication of the infection, eradication depending on the prevalence of strains resistant to antibacterial preparations using for treatment [4]. Currently, the eradication of H. pylori is managed by the use of a triple therapy, involving the co-administration of two antibiotics and a proton pump inhibitor or bismuth during ten or fourteen days. https://lupinepublishers.com...

Mesenteric Venous Ischemia Secondary to Thrombophilia: Case Report by Amer N in Current Trends in Gastroenterology and Hepatology in Lupine Publishers Mesenteric ischaemia is an uncommon condition with high mortality and morbidity, the causes can be embolic, thrombotic arterial or venous. Mesenteric venous thrombosis is an uncommon cause of bowel infarction, and it accounts for only 2-10% of the cases of Mesenteric Bowel ischaemia. We are reporting an interesting and uncommon case a fifty-year-old Filipina lady, not known to have any previous medical problems, presented to us with severe abdominal pain with minimal signs. Her CT scan confirmed Mesenteric Venous ischaemia and Bowel infarction. The lady was found to suffer from Protein C and S deficiency. https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/mesenteric-venous-ischemia-secondary-to-thrombophilia-case-report.ID.000119.php    https://lupinepublishers.com/ga...