Lupine Publishers | Current Trends in Gastroenterology and Hepatology Abstract Over the past several decades, great progress has been made on understanding mechanisms of gastric acid secretion for developing new anti-acid drugs. Until now most commonly used anti-acid drugs are histamine-2 receptor antagonists and proton pump inhibitors (PPIs) for patients to control acid related disease. However, several clinical limitations of these drugs had been reported. Recently, a new generation of potassium-competitive acid blockers (P-CABs) were launched for clinical use. It has been shown that these new drugs are more convenient and powerful to treat gastric acid-related diseases. In this article, we briefly reviewed the clinical use of this new anti-acid drug P-CAB. Keywords: Potassium-competitive Acid Blocker; Potassium channel; H+/K+-ATPase Introduction H+/K+-ATPase (or proton pump), which is expressed in gastric parietal cells, is one of the...