Lupine Publishers Current Trends in Gastroenterology and Hepatology

  Abstract The identification of the calcium ration by self-questionnaires validated in the region of Blida and the Wilayas of approximately is one of the rare studies in Algeria. She was interested in a part of the Algerian population with characteristics that do not seem very different from the general population; however, this dietary survey must be supplemented by a study on a representative sample of the general population. The study showed insufficient calcium intake mainly secondary to low consumption of milk and dairy products. This low calcium intake was objectified by the two questioning methods (Fardellone and CERIN), however, it will be desirable to establish Algerian self-questionnaires validated and verified by our learned society. The results obtained are worrying, which obliges us to immediately introduce a prevention and control strategy against the multiple pathologies linked to this low calcium intake, the main one being osteoporosis with its seri...

  Abstract The identification of the calcium ration by self-questionnaires validated in the region of Blida and the Wilayas of approximately is one of the rare studies in Algeria. She was interested in a part of the Algerian population with characteristics that do not seem very different from the general population; however, this dietary survey must be supplemented by a study on a representative sample of the general population. The study showed insufficient calcium intake mainly secondary to low consumption of milk and dairy products. This low calcium intake was objectified by the two questioning methods (Fardellone and CERIN), however, it will be desirable to establish Algerian self-questionnaires validated and verified by our learned society. The results obtained are worrying, which obliges us to immediately introduce a prevention and control strategy against the multiple pathologies linked to this low calcium intake, the main one being osteoporosis with its se...

  Introduction Aristolochic acid (AAs) is a group of nitrophenanthrene compounds comprised of AAI, AAII, AAIII and AAIV, which are widely found in Aristolochia plants and used in herbal therapy and traditional Chinese medicine [1]. Consistent use of aristolochic acids- containing drugs could lead to aristolochic acid nephropathy and subsequent urinary tract tumors [2-4]. Active metabolites of AAs form adducts with DNA, inducing characteristic A-T transversion (A:T to T:A mutation) known as AA mutational signature [5]. In 2017, a study has analyzed AA mutational signature of several datasets and concluded that AAs and their derivatives were widely implicated in liver cancers in Taiwan and throughout Asia [6]. Ever since the paper published, there has been an intensive debate on whether the prevalence of AA signature mutation is high in HCC patients and if this mutation spectra is really correlate with traditional Chinese medicine consumption in Asia. Since no case report...

  Opinion Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of progressive liver abnormalities from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH) to advanced fibrosis, cirrhosis, and/or hepatocellular carcinoma [1]. Parallel to the rising burden of obesity and metabolic syndrome, NAFLD has emerged as the leading cause of chronic liver disease at an estimated global prevalence of 24% [2]. Besides its known clinical burden for liver-related morbidity and mortality, NAFLD is potentially linked with other extra-hepatic chronic diseases and may be considered a multisystem condition. Particularly, NAFLD increases the risk of type 2 diabetes, cardiovascular diseases, chronic kidney disease, and all-cause mortality [1]. Potential pathophysiologic mechanisms underlying the detrimental effects of NAFLD include hyperglycemia, systemic inflammation, and increased oxidative stress [3]. Sodiumglucose cotransporter 2 (SGLT2) inhibitors are a new class of ...

Abstract Post-COVID-19 gastrointestinal (GI) disease management remains a clinical challenge as the medical literature continues to evolve and expand. Reports of excess GI disease burden across the population, as well as prescribed use of pharmaceuticals for symptom relief, have proven “long-haul” GI disease is prevalent across the population. This article will help to summarize the current medical literature as it pertains to post-COVID-19 GI clinical presentations, dysbiosis, functional disorders and evidence of lasting liver and biliary injury implications. Increased awareness of the GI implications for this paradigm hopefully will lead to a better understanding of the pathophysiology, as well as natural history and potential therapeutic approaches. Read more about this article: https://lupinepublishers.com/gastroenterology-hepatology-journal/fulltext/post-covid-19-gi-manifestations-are-we-in-for-the-long-haul.ID.000158.php  Read more about Lupine Publishers Go...

  Abstract Aim : To determine the aetiologies of acute upper gastrointestinal bleeding (UGIB) in a setting highly endemic for hepatitis B and to describe actual clinical practices in a resource-limited setting. Patients and methods: This study was conducted in two parts. The first part was retrospective from January 1st 2010, to December 31st 2019 on the epidemiological profile of UGIB and the second was a prospective study from December 1st 2017 to May 31st 2018 to evaluate, in a blinded experiment, the actual clinical practices in front of an acute UGIB at the emergency units in Yaounde (Cameroon), and included: recognizing UGIB, assessing for severity, taking emergency measures and prescribing emergency Eosogastroduodenal endoscopy (EGDE). Results : During the retrospective period, 506 patients (prevalence of acute UGIB in the services 5.6%) were included of which 71.3% were men (sex ratio 2.5). The mean age was 49.9 +/- 8 years. Haematemesis was inaugural in 35...